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Deep brain stimulation for torsion dystonia in children
Ron L Alterman1, Michele Tagliati
1Department of Neurosurgery, Mount Sinai Medical Center, One Gustave L. Levy Place, P.O. Box 1136, New York, NY 10029, USA. ron.alterman@mountsinai.org
Introduction:
Deep brain stimulation (DBS) at the internal globus pallidus (GPi) is an effective treatment for some patients with medically refractory torsion dystonia. In this article, we review the results of pallidal DBS surgery in children with dystonia. Details of the DBS procedure and programming of the DBS devices are discussed.
Discussion:
Pallidal DBS is most effective in patients with primary generalized dystonia. Children and adolescents possessing the DYT1 gene mutation may respond best of all. The presence of static dystonic postures and/or fixed orthopedic contractures may limit the functional response to DBS and may require additional surgery.
Conclusion:
As a group, patients with secondary dystonias respond less well to DBS than patients with primary dystonia. However, patients with dystonia secondary to anoxic brain injury who have grossly intact basal ganglia anatomy may represent a subpopulation for whom pallidal DBS is a viable option.
