Battery Longevity in Deep Brain Stimulation for Parkinson's Disease

Area of Science:

• Neurology
• Biomedical Engineering
• Medical Devices

Background:

• Implanted pulse generator (IPG) longevity in deep brain stimulation (DBS) therapy is crucial for patients with Parkinson's Disease (PD).
• Advancements include longer-lived batteries, both standard and rechargeable, impacting device lifespan.
• Factors influencing IPG longevity include diagnosis, target, device type, lead number, and stimulation parameters.

Purpose of the Study:

• To assess the estimated IPG longevity of the Medtronic Percept™ PC neurostimulator in PD patients.
• To explore factors associated with IPG lifespan in this population.

Main Methods:

• Retrospective analysis of 31 PD patients with bilateral DBS targeting the internal globus pallidus or subthalamic nucleus.
• Included analysis of demographics, clinical data, stimulation settings, lead locations, and Total Effective Energy Delivered (TEED).

Main Results:

• Median IPG longevity was 75.9 months.
• Frequency, pulse width, TEED, amplitude, and voltage showed significant inverse correlations with longevity.
• Monopolar stimulation on the dominant side was associated with significantly longer IPG longevity (80.6 vs 49.6 months).

Conclusions:

• Stimulation parameters significantly negatively correlate with IPG longevity in PD patients undergoing DBS.
• Monopolar stimulation on the dominant side is linked to increased IPG longevity, offering potential for optimized therapeutic strategies.