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Updated: Jul 14, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Expression level of beta-catenin is associated with prognosis of esophageal carcinoma
Lv Ji1, Xiu-Feng Cao, He-Ming Wang
1Affillted Nanjing First Hospital Oncology Center, Nanjing Medical University, Changle Road, Nanjing, Jiangsu Province, China.
Aim:
To examine the association of beta-catenin with the clinicopathologic features and prognosis of esophageal squamous cell carcinoma (ESCC).
Methods:
Beta-catenin mRNA expression level in 40 ESCC patients (28 males and 12 females, age range 38-82 years, median 60 years) was analyzed by real-time PCR. Beta-catenin mRNA expression levels in tumor cells were categorized as weaker (level 1) or equal to or stronger (level 2) than those in endothelial cells. We examined the correlation between the beta-catenin expression and the clinicopathological factors and prognosis of ESCC patients.
Results:
Level 2 beta-catenin expression was found in 29 patients. ESCC with level 2 expression had a higher rate of lymphnode metastasis (0.0776 +/- 0.0369 vs 0.3413 +/- 0.1803, P < 0.001) and deeper tumor invasion (0.0751 +/- 0.0356 vs 0.3667 +/- 0.1928, P < 0.001), and a poorer survival rate (P = 0.0024) than ESCC with level 1 expression.
Conclusion:
Beta-catenin expression in ESCC is of great importance.
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