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gyrA mutations in fluoroquinolone-resistant Clostridium difficile PCR-027

Denise Drudy, Lorraine Kyne, Rebecca O'Mahony

    Emerging Infectious Diseases
    |June 8, 2007
    PubMed
    Summary

    No abstract available in PubMed .

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    Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These antibiotics are selectively...

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