Relationship between vitamin D binding protein and aspirin resistance in coronary ischemic patients: a proteomic
Antonio J López-Farré1, Petra J Mateos-Cáceres, Daniel Sacristán
1Cardiovascular Research and Coronary Units, Cardiovascular Institute, and Immunology Department, Hospital Clínico San Carlos, Madrid, Spain.
Abstract:
Our aim was to analyze the plasma proteome in aspirin (acetylsalicylic acid [ASA])-sensitive and ASA-resistant coronary ischemic patients. Plasma from 19 ASA-sensitive and 19 ASA-resistant patients was analyzed. For the proteomic study, two-dimensional electrophoresis was performed. The expression of one isotype of the fibrinogen gamma chain and three isotypes of haptoglobin was increased in ASA-resistant patients. Three vitamin D binding protein isotypes were increased in ASA-resistant patients. In vitro incubation of vitamin D binding protein (DBP) with blood from healthy volunteers reduced the inhibitory effect of ASA on thromboxane A2 production. DBP may be a new regulator of the inhibitory effect of ASA on platelets.
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