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Outcomes and prognosis in advanced renal cell carcinoma

Matthew D Galsky1, Nicholas J Vogelzang

  • 1Genitourinary Oncology Program, US Oncology Research, Las Vegas, Nevada, USA. matthew.galsky@usoncology.com

Expert Review of Anticancer Therapy
|June 9, 2007
PubMed

Insights

Understanding renal cell carcinoma pathogenesis led to new treatments. Past studies defining outcomes and prognostic factors for advanced disease are crucial for future clinical trials and patient selection.

Area of Science:

  • Oncology
  • Nephrology

Background:

  • Recent advances in understanding renal cell carcinoma (RCC) pathogenesis have spurred therapeutic progress.
  • The US FDA has approved targeted therapies like sunitinib and sorafenib for advanced RCC.
  • Prior clinical research has been instrumental in defining outcomes and prognostic factors in advanced RCC.

Purpose of the Study:

  • This review focuses on studies that define the outcome and prognosis in advanced renal cell carcinoma.
  • To provide context for interpreting future clinical trials with novel agents.
  • To guide patient selection for specific therapeutic approaches and stratify patients in randomized trials.

Main Methods:

  • Review of clinical trials and observational studies.
  • Analysis of data defining outcomes and prognostic factors in advanced renal cell carcinoma.
  • Synthesis of existing literature on patient outcomes and prognostication.

Main Results:

  • Past studies have established critical benchmarks for evaluating new RCC therapies.
  • Identifying major prognostic factors aids in optimizing patient selection for targeted treatments.
  • Understanding outcomes provides a framework for interpreting results from ongoing and future clinical trials.

Conclusions:

  • Defining outcomes and prognostic factors in advanced renal cell carcinoma is essential for therapeutic progress.
  • This foundational work supports the development and interpretation of novel treatment strategies.
  • Continued research in prognostication will enhance personalized treatment approaches for advanced RCC patients.

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