Related Experiment Video
Updated: Jul 14, 2026

Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model
Published on: September 20, 2020
Impaired longitudinal myocardial velocities in patients with growth hormone deficiency improves after hormone
Ibrahim Ozdogru1, Fatih Tanriverdi, Ali Dogan
1Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey. iozdogru@erciyes.edu.tr <iozdogru@erciyes.edu.tr>
Abstract:
Cardiac parameters in growth hormone (GH) deficiency and the effects of GH replacement treatment (GHRT) are still controversial. We investigated 19 adult patients (mean age: 45 +/- 10 years, 7 male), with GH deficiency before and after 12 months of GHRT. Twenty age- and sex-matched healthy individuals (mean age: 44 +/- 12 years, 9 male) were taken as a control group. All participants underwent echocardiography both before and after GHRT. The patients before GHRT and control subjects had similar left ventricular sizes and ejection fraction whereas patients before GHRT had impaired diastolic indices of left ventricle. Peak systolic annular velocity, which identifies myocardial longitudinal systolic function, was lower in patients before GHRT than in the control subjects (0.08 +/- 0.01 vs 0.10 +/- 0.02, P < .05) and improved after GHRT (0.09 +/- 0.03, P < .05). Adult-onset GH deficiency is associated with normal left ventricular sizes and preserved ejection fraction whereas longitudinal systolic function obtained by Doppler tissue imaging is deteriorated, which improves with 12 months of GHRT.
Related Concept Videos
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Cellular Adaptation II: Hypertrophy
Heart Failure II: Pathophysiology
Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Cardiomyopathy V: Interprofessional Care
