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Adipose tissue in the lens.

¹Department of Ophthalmology, University of Tennessee, Memphis 38163.

Annals of Ophthalmology

|October 1, 1991

Summary

A rare case of persistent hyperplastic primary vitreous (PHPV) was found in a 31-year-old man, featuring adipose tissue replacing the lens. This unusual finding has only been documented in two other reported cases globally.

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Area of Science:

Ophthalmology
Medical Case Reports
Vitreoretinal Surgery

Background:

Persistent hyperplastic primary vitreous (PHPV) is a congenital developmental anomaly of the eye.
It typically results from the failure of regression of the primary vitreous and tunica vasculosa lentis.
PHPV can lead to significant visual impairment and is often associated with other ocular abnormalities.

Observation:

A unique case of PHPV was identified in a 31-year-old male patient.
The primary observation was the complete replacement of the native lens by adipose tissue (lipomatous replacement).
This specific histopathological finding is exceptionally rare within the spectrum of PHPV.

Findings:

The case presented a severe form of PHPV.
The most striking finding was the lens being substituted by adipose tissue, a phenomenon rarely described.
Literature review confirmed the extreme rarity, with only two prior documented instances of this specific presentation.

Implications:

This case expands the understanding of the phenotypic variability of PHPV.
It highlights the importance of considering unusual pathological changes in persistent hyperplastic primary vitreous.
Further research may elucidate the specific developmental pathways leading to lipomatous replacement of the lens in PHPV.

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