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Conversion of bromperidol to reduced bromperidol in human liver
T Someya1, T Inaba, R F Tyndale
1Department of Psychiatry, Shiga University of Medical Science, Otsu, Japan.
Abstract:
Bromperidol (BRP) is an analog of haloperidol, a potent butyrophenone neuroleptic. Reductive conversion of BRP carbonyl group to reduced bromperidol (RBRP) was confirmed in vitro using human liver. This NADPH-dependent reduction of BRP showed a similar inhibition pattern and Michaelis constants to haloperidol carbonyl reductase.