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Protein tumor antigens.

P K Srivastava1

  • 1Mount Sinai School of Medicine, New York.

Current Opinion in Immunology
|October 1, 1991
PubMed
Summary

Researchers are identifying novel tumor antigens, including stress-induced proteins and mucins, crucial for cancer immunotherapy. Understanding these antigens, like p53 and gp95/p97, advances cancer treatment strategies.

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Area of Science:

  • Oncology
  • Immunology
  • Biochemistry

Background:

  • Identifying immunogenic tumor antigens is critical for developing effective cancer immunotherapies.
  • Advances in understanding antigen presentation have reshaped the search for these crucial molecules.

Purpose of the Study:

  • To review the expanding repertoire of known tumor antigens.
  • To highlight key examples of immunogenic tumor antigens and their significance.

Main Methods:

  • Literature review and synthesis of current research on tumor antigens.
  • Discussion of specific antigen classes and examples.

Main Results:

  • Several classes of tumor antigens are identified, including stress-induced proteins, P1AB, p53, gp95/p97, and mucins.
  • These antigens represent a growing resource for cancer vaccine and therapy development.

Conclusions:

  • The discovery and characterization of immunogenic tumor antigens are accelerating.
  • These antigens hold significant promise for the future of cancer immunotherapy.

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