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Growth of infants with IgE-mediated cow's milk allergy fed different formulas in the complementary feeding period

Carlo Agostoni1, Alessandro Fiocchi, Enrica Riva

  • 1Department of Pediatrics, San Paolo Hospital, University of Milan, Milan, Italy. carlo.agostoni@unimi.it

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|June 15, 2007
PubMed

Insights

For infants with cow's milk allergy (CMA), hydrolyzed formulas may support better weight gain compared to soy formulas during complementary feeding. Continued research is needed to optimize nutrition for allergic infants.

Area of Science:

  • Pediatrics
  • Allergy and Immunology
  • Nutrition Science

Background:

  • Infants with allergies, including cow's milk allergy (CMA), often experience growth issues.
  • Dietary interventions during the complementary feeding period are crucial for managing growth in allergic infants.

Purpose of the Study:

  • To assess if different milk types during complementary feeding (6-12 months) impact growth indices in infants with immunoglobulin E-mediated CMA.
  • To compare standardized growth indices (weight-for-age, length-for-age, weight-for-length z-scores) across various infant formulas and breastfeeding.

Main Methods:

  • Randomized controlled trial comparing soy, casein hydrolysate, and rice hydrolysate formulas.
  • A non-randomized group of breastfed infants was included for comparison.
  • Growth z-scores (WA, LA, WL) were measured at 6, 9, and 12 months of age.

Main Results:

  • All groups exhibited low weight-for-age (WA) and length-for-age (LA) z-scores at 6 months.
  • Hydrolyzed formulas showed a trend towards greater WA z-score increases from 6 to 12 months.
  • Casein and rice hydrolysate formulas led to more significant WA changes than soy formula.

Conclusions:

  • The type of milk during complementary feeding influences growth trajectories in infants with CMA.
  • Hydrolyzed formulas, particularly casein and rice-based, may offer advantages over soy formula for weight gain in this population.
  • Further research is essential to refine dietary recommendations for infants with CMA.

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