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Related Experiment Video

Updated: Jul 14, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

Bladder sensory desensitization decreases urinary urgency.

Carlos Silva1, João Silva, Helder Castro

  • 1Department of Urology, Hospital S, João and Faculty of Medicine of Porto, Porto, Portugal. carsil@med.up.pt <carsil@med.up.pt>

BMC Urology
|June 15, 2007
PubMed
Summary

Bladder desensitization using RTX significantly reduced urgency episodes in overactive bladder patients. This treatment offers a promising alternative for managing refractory urgency, with most patients willing to repeat the procedure.

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Detrusor Underactivity Model in Rats by Conus Medullaris Transection
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Published on: August 28, 2020

Related Experiment Videos

Last Updated: Jul 14, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Area of Science:

  • Urology
  • Pharmacology

Background:

  • Refractory detrusor overactivity and overactive bladder (OAB) affect over 10% of the Western population.
  • Current first-line treatments for OAB, such as anti-muscarinic drugs, often fail to fully control urgency.
  • Bladder desensitization is being explored as an alternative therapeutic approach.

Purpose of the Study:

  • To evaluate the effect of bladder desensitization on urinary urgency in patients with OAB.
  • To investigate the efficacy of RTX (a TRPV1 agonist) in reducing urgency episodes.

Main Methods:

  • An exploratory study involving 23 OAB patients with refractory urgency.
  • Patients underwent a run-in period, followed by instillations of a vehicle solution and then 50 nM RTX.
  • Urgency episodes were quantified using voiding charts scored on a 0-4 scale before each voiding.

Main Results:

  • After RTX instillation, the mean number of urgency episodes per week decreased significantly from 71 (baseline) to 39 at 1 month (p=0.002) and 37 at 3 months (p=0.02).
  • In contrast, a vehicle solution showed a less pronounced reduction in urgency episodes (56 per week).
  • 69% of patients reported subjective improvement after RTX and expressed willingness to repeat the treatment.

Conclusions:

  • Bladder desensitization with RTX demonstrates potential as an alternative treatment for OAB patients with refractory urgency.
  • The findings suggest that urothelium and sub-urothelial C-fibers, targeted by RTX via TRPV1 receptors, play a crucial role in urgency sensation generation.