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Glucuronic acid-based ulosyl donors for introducing alpha-D-GlcA and beta-D-ManA units
Matthias Lergenmüller1, Frieder W Lichtenthaler
1Clemens-Schöpf-Institut für Organische Chemie und Biochemie, Technische Universität Darmstadt, D-64287 Darmstadt, Germany.
Abstract:
Practical protocols are described for a five-step conversion of D-glucuronolactone into alpha-D-arabino-2-ketoglucuronyl bromides, which due to their alpha-selective or beta-specific glycosidation, and gluco- or manno-specific carbonyl reductions of the glucurono-2-ulosides formed, are expedient indirect donor substrates for the efficient introduction of alpha-D-GlcA or beta-D-ManA residues.
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