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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Independent components of chronic kidney disease as a cardiovascular risk state: results from the Kidney Early

Peter A McCullough1, Claudine T Jurkovitz, Pablo E Pergola

  • 1Division of Cardiology, William Beaumont Hospital, Royal Oak, MI 48073, USA. pmc975@yahoo.com

Archives of Internal Medicine
|June 15, 2007
PubMed

Insights

Anemia, microalbuminuria, and reduced estimated glomerular filtration rate (eGFR) are independently linked to cardiovascular disease (CVD). The presence of all three significantly increases CVD risk and reduces survival rates.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • The independent associations of anemia, microalbuminuria, and estimated glomerular filtration rate (eGFR) with cardiovascular disease (CVD) and mortality require further investigation.
  • Chronic kidney disease (CKD) encompasses these interrelated measures, impacting patient outcomes.

Purpose of the Study:

  • To investigate the independent relationships between anemia, microalbuminuria, and eGFR with the incidence of cardiovascular disease (CVD).
  • To determine the combined impact of these CKD-related markers on patient mortality.

Main Methods:

  • A cohort of 37,153 participants from the Kidney Early Evaluation Program were followed for a median of 16.0 months.
  • Data collected included medical history, blood pressure, and laboratory tests, with eGFR calculated using a 4-variable equation.
  • Mortality outcomes were ascertained through linkage to national data systems.

Main Results:

  • Anemia (hemoglobin ≤ 12.8 g/dL), microalbuminuria (> 30 mg/L), and reduced eGFR (30-59 mL/min/1.73 m²) were independently associated with CVD.
  • Male sex, smoking, obesity, diabetes, and hypertension were also significant risk factors for CVD.
  • CVD, CKD, and their combination independently predicted mortality, with the presence of all three CKD markers associated with the lowest survival (~93% at 30 months).

Conclusions:

  • Anemia, impaired eGFR, and microalbuminuria are independent risk factors for CVD.
  • The co-occurrence of these three CKD markers significantly elevates CVD prevalence and is associated with reduced survival.
Abstract

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