[Clinicopathological study of invasive pulmonary aspergillosis complicated by leukemia]

We assessed the clinicopathological features of invasive pulmonary aspergillosis.

We conducted chest radiograph-pathologic correlations in 8 cases with invasive pulmonary aspergillosis diagnosed at autopsy.

Subjects were 4 men and 4 women with a mean age of 57.4 years and all having leukemia as an underlying hematological disorder. All had been treated with anticancerous drugs and corticosteroids. Histopathologically, coagulation necrosis with marginal hemorrhage and agranulocytosis were observed in 6 whose initial abnormal shadows in chest X-ray appeared during the neutropenic phase less than 500/microL. In contrast, numerous infiltration of neutrophils and colliquation necrosis at the center of lesions were observed in 2 whose initial abnormal shadows in chest X-ray appeared having more than 500/microL of neutrophils in the peripheral blood.