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IL-15 levels in patients with acute hepatic failure

Chikara Yonekawa1, Hajime Nakae, Ya-Juan Zheng

  • 1Department of Integrated Medicine, Division of Emergency and Critical Care Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan. yone-c@sc4.so-net.ne.jp

Research Communications in Molecular Pathology and Pharmacology
|June 15, 2007
PubMed

Interleukin (IL)-15, an inhibitor of tumor necrosis factor (TNF)-alpha, causes liver injury in mice. We determined levels of IL-15, IL-6, and IL-18 by enzyme-linked immunosorbent assays in 20 patients with acute hepatic failure and examined relationship between these proinflammatory cytokines and IL-15. A significant correlation was observed between the levels of IL-18 and IL-15 (p = 0.0118). IL-15 levels in the nonsurvivors were significantly higher than those in the survivors (p = 0.0357). Our results suggest that IL-15 overexpression may cause liver injury in human.

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