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Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
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Related Experiment Video

Updated: Jul 14, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
11:38

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Published on: May 10, 2016

Risk management measures for chemicals: the "COSHH essentials" approach.

A N I Garrod1, P G Evans, C W Davy

  • 1Health and Safety Executive, Redgrave Court, Bootle, Merseyside, UK.

Journal of Exposure Science & Environmental Epidemiology
|June 15, 2007
PubMed
Summary

COSHH essentials provides a simple, empirical tool for managing chemical risks, aligning with REACH regulations. This popular online resource offers practical guidance for workplace safety and compliance.

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Area of Science:

  • Occupational Hygiene
  • Chemical Safety Regulations

Background:

  • The Control of Substances Hazardous to Health (COSHH) Regulations in Great Britain require duty holders to manage chemical risks.
  • The European REACH Regulation (Registration, Evaluation, Authorisation and Restriction of Chemicals) also focuses on risk management for chemical substances.
  • COSHH essentials was developed to aid compliance with UK COSHH Regulations and shares principles with the REACH Regulation.

Purpose of the Study:

  • To explore the utility of "COSHH essentials" as a tool for communicating risk-management measures.
  • To highlight its role in assisting duty holders under both COSHH and REACH regulations.
  • To demonstrate its effectiveness in providing a benchmark for good practice in chemical safety.

Main Methods:

  • Utilizes an empirical approach for risk assessment and management.
  • Outputs "Control Guidance Sheets" detailing "dos" and "don'ts" for specific task scenarios.
  • Incorporates administrative and behavioral controls alongside mechanical ones.

Main Results:

  • COSHH essentials provides a straightforward method for identifying and communicating risk-management measures.
  • Freely available online since 2002, it facilitates links between shared tasks and ancillary guidance.
  • The tool has gained significant popularity, attracting over 1 million visits, indicating its value as a communication benchmark.

Conclusions:

  • COSHH essentials is an effective and popular tool for communicating good control practices in chemical handling.
  • It serves as a valuable resource for various stakeholders, including chemical users, manufacturers, suppliers, importers, regulators, and health professionals.
  • Its alignment with REACH principles enhances its applicability for European chemical safety compliance.