Related Experiment Video
Updated: Jul 14, 2026
10:44
A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function
Published on: June 2, 2019
Activated T lymphocytes in pre-eclampsia.
D Darmochwal-Kolarz1, S Saito, J Rolinski
1Department of Obstetrics and Perinatology, Skubiszewski Medical University of Lublin, Lublin, Poland. dorotak@mp.pl
Summary
Pre-eclampsia (PE) is linked to lower T regulatory cells and higher activated T cells (CD4+CD45RO+, CD8+CD25+). This suggests T cell activation may be associated with T regulatory cell deficiency in PE.
Area of Science:
- Immunology
- Obstetrics
Background:
- Pre-eclampsia (PE) is a serious pregnancy complication.
- Immune system dysregulation is implicated in PE pathogenesis.
Purpose of the Study:
- To investigate T cell activation and regulatory populations in women with PE.
- To compare T cell subsets between PE patients and healthy pregnant women.
Main Methods:
- Flow cytometry was used to analyze peripheral blood mononuclear cells.
- Twenty-five PE patients and thirty healthy pregnant women were studied.
Main Results:
- T regulatory CD4(+)CD25(bright) cells were significantly lower in PE patients (P < 0.01).
- Activated T cells, including CD4(+)45RO(+) (P < 0.01) and CD8(+)CD25(+) (P < 0.05), were significantly higher in PE.
- Naïve T cells (CD4(+)CD45RA(+)) were significantly lower in PE patients (P < 0.01).
Conclusions:
- Increased CD4(+)45RO(+) and CD8(+)CD25(+) cells suggest T lymphocyte activation in PE.
- T lymphocyte activation in PE may be linked to a deficiency in T regulatory cells.
Related Concept Videos
01:22Development of Immunocompetence
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
01:15Transcytosis of IgG
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...