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Analgesia by nefopam: does it act through serotonin?
D Marazziti1, A Rotondo, F Ambrogi
1Institute of the Psychiatric Clinic, University of Pisa, Italy.
Drugs Under Experimental and Clinical Research
|January 1, 1991
Abstract:
In an attempt to clarify the possible mode of action of nefopam, a new analgesic compound, the authors tested its effects on imipramine (IMI) binding to platelet membranes. The results showed that nefopam exerted a concentration-dependent inhibition of IMI binding, with a potency comparable to that of tricyclic antidepressants. This finding suggests a possible intervention of serotonergic mechanisms in nefopam-related analgesia.