New salirepin derivatives from Symplocos racemosa

Area of Science:

• Natural Product Chemistry
• Phytochemistry
• Organic Chemistry

Background:

• Symplocos racemosa Roxb. is a plant species with potential medicinal properties.
• Phytochemical investigations aim to identify bioactive compounds from plant sources.
• Phenolic glycosides are a class of compounds with diverse biological activities.

Purpose of the Study:

• To isolate and characterize new chemical constituents from the bark of Symplocos racemosa.
• To identify novel phenolic glycosides belonging to the salirepin series.
• To confirm the presence of known compounds like salirepin in the plant.

Main Methods:

• Extraction of the n-butanol soluble fraction from the plant bark.
• Isolation of compounds using chromatographic techniques.
• Structure elucidation of isolated compounds using 1D and 2D Nuclear Magnetic Resonance (NMR) spectroscopy.
• Analysis of other spectral data (e.g., Mass Spectrometry) and comparison with existing literature.

Main Results:

• Two new phenolic glycosides, symplocuronic acid (1) and sympocemoside (2), were isolated and identified.
• Salirepin (3) was isolated from Symplocos racemosa for the first time.
• The structures were confirmed through comprehensive spectroscopic analysis and literature comparison.

Conclusions:

• The phytochemical investigation successfully identified novel compounds from Symplocos racemosa.
• The findings expand the knowledge of the chemical diversity within the salirepin series.
• This study contributes to the understanding of the phytochemistry of Symplocos racemosa.