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RNA Structure

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...

RNA Stability

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...

RNA Structure

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...

RNA Stability

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...

Experimental RNAi

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...

RNA Structure

RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...

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Related Experiment Video

Updated: Jun 18, 2026

RNA Secondary Structure Prediction Using High-throughput SHAPE

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

RSRE: RNA structural robustness evaluator.

Wenjie Shu¹, Xiaochen Bo, Zhiqiang Zheng

¹Beijing Institute of Radiation Medicine, Beijing 100850, China.

Nucleic Acids Research

|June 15, 2007

Summary

This summary is machine-generated.

Biological robustness, the ability of biological systems to maintain function under stress, is crucial. The RNA Structural Robustness Evaluator (RSRE) provides a computational tool to quantify RNA structural robustness, aiding evolutionary studies.

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Area of Science:

* Molecular Biology
* Bioinformatics
* Evolutionary Biology

Background:

* Biological robustness is key to stable cellular function despite perturbations.
* Understanding RNA structural robustness is vital but lacks sufficient computational evidence.
* Previous studies explored RNA structural robustness, yet its origins remain debated.

Purpose of the Study:

* To introduce the RNA Structural Robustness Evaluator (RSRE) web server.
* To provide a freely accessible online tool for quantitative RNA structural robustness assessment.
* To support the exploration of RNA structural robustness and evolution.

Main Methods:

* Utilizes a quantitative evaluation of RNA structural robustness based on neutrality.
* Employs classical structure comparison methods and five randomization techniques for control sequences.
* Incorporates optional sub-optimal structure prediction to address secondary structure prediction uncertainty.

Main Results:

* The RSRE web server offers a user-friendly interface for evaluating RNA structural robustness.
* Provides intuitive illustrations alongside computational results for enhanced analysis.
* Facilitates quantitative assessment of RNA structural robustness.

Conclusions:

* The RSRE web server is a valuable resource for exploring RNA structural robustness.
* This tool can advance our understanding of RNA evolution and functional stability.
* Freely available online tool aids research in molecular biology and bioinformatics.