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Updated: Jul 14, 2026

Isolation, Identification, and Purification of Murine Thymic Epithelial Cells
07:20

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Published on: August 8, 2014

Thymosin alpha1: a historical overview

Enrico Garaci1

  • 1Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Presidenza@iss.it

Annals of the New York Academy of Sciences
|June 15, 2007
PubMed

Thymosin alpha 1 (Talpha1), initially isolated from thymus, was characterized by Allan Goldstein in 1977. Since the beginning, our studies were aimed at evaluating its immunomodulating effects when used in combination with cytokines and chemotherapy. Combination therapies have now proved to be effective in inhibiting tumoral growth and in controlling infective diseases especially in the immunocompromised host. More recent studies showed that Talpha1 molecule increased major histocompatibility complex (MHC) class-1 and Toll-like receptor expression as well as cytokine production, suggesting its immunoregulatory role. Overall these results led us to start pilot clinical trials on patients with hepatitis C and cancer.

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