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Published on: March 27, 2018
Smoking cessation is associated with reduced long-term mortality and the need for repeat interventions after coronary
Athanasios Papathanasiou1, Haralampos Milionis, Ioannis Toumpoulis
1Department of Cardiology, University Hospital of Ioannina, Ioannina, Greece.
Insights
Smoking cessation after coronary artery bypass grafting (CABG) significantly reduces long-term mortality and the need for repeat procedures. Continued smoking post-CABG is linked to increased cardiovascular death and revascularization needs.
Area of Science:
- Cardiology
- Public Health
- Thoracic Surgery
Background:
- Coronary artery bypass grafting (CABG) is a common procedure for severe coronary artery disease.
- Smoking is a major risk factor for cardiovascular disease and impacts surgical outcomes.
- The long-term effects of continued smoking versus cessation after CABG require further elucidation.
Purpose of the Study:
- To assess the impact of smoking cessation on long-term mortality after CABG.
- To evaluate the effect of smoking status on the need for repeat revascularization procedures post-CABG.
Main Methods:
- Prospective study design.
- Inclusion of 1027 patients undergoing their first-ever CABG.
- Follow-up over 5310 patient-years, comparing current smokers, quitters, and never smokers.
Main Results:
- Among 640 active smokers, 44.7% continued smoking post-CABG.
- Current smokers, compared to never smokers, showed a 2.6-fold increased risk of total mortality and a 4.8-fold increased risk of cardiovascular mortality.
- Current smokers also had a 1.7-fold increased risk of requiring a repeat revascularization procedure.
Conclusions:
- Smoking cessation after CABG is associated with improved long-term survival.
- Continued smoking post-CABG significantly increases mortality, particularly cardiovascular mortality.
- Smoking cessation is crucial for reducing the need for repeat revascularization procedures in CABG patients.
Design:
A prospective study.
Methods:
We estimated the impact of smoking cessation on long-term mortality and the need for a revascularization procedure in 1027 patients undergoing a first-ever coronary artery bypass-grafting.
Results And Discussion:
Of the 640 active smokers, 44.7% continued smoking after CABG ('current smokers'), and 55.3% quit. During a 5310 patient-years follow-up, with never smokers as the reference group, current smokers (but not quitters) experienced a significant increase in total mortality (hazard ratio 2.6, 95% confidence interval 1.0-6.6) mainly owing to increased cardiovascular mortality (hazard ratio 4.8, 95% confidence interval 1.1-21.4), as well as increased need for a repeat revascularization procedure (hazard ratio 1.7, 95% confidence interval 1.0-2.9).
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