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Updated: Jul 14, 2026

Intracranial Pharmacotherapy and Pain Assays in Rodents
Published on: April 9, 2019
[Study on the pharmacological mechanism of analgesic effect of injection stauntoniae]
Su Chen1, Xiang-ming Liu, Fan Zhang
1Department of Biological and Medical Engineering, South-Central Universityr for Nationalities, Wuhan (430074).
Objective:
To study the effects of Injection Stauntoniae (IS) on voltage-gated sodium currents in dorsal root ganglion neurons and analyze its pharmacological mechanism of blocking the nerve conduction and anal gesic action.
Methods:
Whole-cell patch-clamp recordings were performed in acutely isolated rat dorsal root ganglion neurons and the effects of 10% , 25% and 50 % IS on voltage-gated sodium currents were observed.
Results:
IS inhibited the peak sodium currents in dorsal root ganglion neurons in a dose-dependent way and affected the activation and inactivation process of the channels.
Conclusion:
The analgesic effect of IS was presumably caused by modulation of voltage-gated sodium channels in primary sensory neurons besides structure destruction of myelin sheath and axon membrane.
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