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Updated: Jul 14, 2026
In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease
Published on: July 19, 2024
[Experimental study on effects of emodin on nonalcoholic fatty liver induced by high fat diet in rats]
Hui Dong1, Fu-er Lu, Zhi-qiang Gao
1Institute of Integrated Chinese and Western Medcine, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan (430030). 13hui@sohu.com
Objective:
To investigate the therapeutic effect of emodin on nonalcoholic fatty liver (NAFL) induced by high fat diet in rats.
Methods:
NAFL model was established by feeding with high fat diet for 12 weeks in 40 SD rats, confirmed by liver pathologic examination, which were randomly divided into 5 groups: the model control group the mere dietary treatment group (both with distilled water by gastrgarege), the low, moderate and high dose emodin groups treated with emodin 20,40 and 80 mg x kg(-1) x d(-1) once per day respectively. Meanwhile a normal control group was used. The model control group was still fed with high fat diet while the other groups with normal diet. After 4 weeks, body weight, liver index (liver weight/body weight), hepatic function, blood lipid, hepatic lipid and histologic changes were assayed.
Results:
In the model control group,body weight, liver index, hepatic enzyme activities, serum lipid and hepatic triglyceride increased significantly (P <0. 05, or P <0. 01), serum high density lipoprotein-cholesterol( HDL-C)decreased (P <0.01 ), and moderate to severe hepatocyte steatosis was observed, while these indexes were all improved significantly in the 3 emodin groups; hepatic histologic changes were improved in the mere dietary treatment group, however, high level of ALT and hyperlipidemia persisted.
Conclusion:
Emodin combined with dietary therapy is effective for NAFL rats induced by high fat diet.
