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Updated: Jul 14, 2026

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Lymph node biopsy results for desmoplastic malignant melanoma.

Deborah L Cummins1, Clemens Esche, Terry L Barrett

  • 1Department of Dermatology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA. dlcummins@gmail.com

Cutis
|June 16, 2007
PubMed
Summary

Desmoplastic malignant melanoma (DMM) rarely spreads to lymph nodes. Sentinel lymph node biopsy (SLNB) in DMM patients showed a low positive rate, suggesting it may not be as crucial for prognosis as in other melanoma types.

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Area of Science:

  • Oncology
  • Dermatology
  • Surgical Pathology

Background:

  • Desmoplastic malignant melanoma (DMM) is a rare melanoma variant.
  • DMM exhibits distinct histopathologic and clinical features, including higher local recurrence and perineural invasion.
  • DMM has a lower risk of distant metastasis compared to other melanoma types.

Purpose of the Study:

  • To characterize DMM.
  • To determine the frequency of histologically positive lymph nodes in DMM patients.
  • To clarify the role of lymph node assessment in DMM prognosis.

Main Methods:

  • Retrospective chart review of DMM patients treated at Johns Hopkins Hospital (1998-2003).
  • Analysis of lymph node biopsy results, including sentinel lymph node biopsy (SLNB) and radical neck dissections.

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  • Histopathological examination and S100 staining of lymph nodes.

    • Main Results:

    • 18 of 28 DMM patients underwent lymph node biopsy (15 SLNBs, 3 radical neck dissections).
    • Only one patient had a positive sentinel lymph node for DMM.
    • All other lymph node biopsies were negative for DMM via histology and S100 stains.

    Conclusions:

    • The frequency of positive SLNBs in DMM appears substantially lower than in other melanoma subtypes.
    • The utility of SLNB for prognostication in DMM warrants further investigation.
    • Current findings suggest a potentially limited role for routine SLNB in managing DMM.