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Related Experiment Videos

APRIL polymorphism and systemic lupus erythematosus (SLE) susceptibility.

Y H Lee1, F Ota, X Kim-Howard

  • 1Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, College of Medicine, Korea University, Seoul, Korea.

Rheumatology (Oxford, England)
|June 16, 2007
PubMed
Summary
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The APRIL gene

Area of Science:

  • Genetics
  • Immunology
  • Rheumatology

Background:

  • Two novel non-synonymous polymorphisms in the APRIL gene (codon 67 and 96) were identified.
  • The APRIL codon 67 (rs11552708) G allele was previously linked to systemic lupus erythematosus (SLE) in Japanese individuals.

Purpose of the Study:

  • To determine if the APRIL codon 67 polymorphism associated with SLE susceptibility in Japanese populations is also associated in other ethnic groups.
  • Investigate the genetic association of APRIL gene polymorphisms with SLE across diverse ethnicities.

Main Methods:

  • Genotyping of APRIL codon 67 and 96 in 348 SLE patients and 345 controls from European-American, African-American, and Hispanic ancestries.
  • Statistical analysis using chi-square and logistic regression, adjusting for ethnicity.

Related Experiment Videos

Main Results:

  • The APRIL codon 67 polymorphism was significantly associated with SLE risk (OR 1.45, 95% CI 1.02-2.06, P=0.036) under a dominant model, adjusted for ethnicity.
  • A trend for association was observed in African-American and Hispanic SLE subjects in race-specific analyses.
  • Both single-nucleotide polymorphisms (SNPs) were in Hardy-Weinberg equilibrium within each ethnic group.

Conclusions:

  • The APRIL codon G67R polymorphism, previously linked to SLE in Japanese individuals, shows potential association with SLE in other populations.
  • This finding suggests a broader role for the APRIL gene in SLE pathogenesis across different ethnic backgrounds.