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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

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The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

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The segmentation clock in mice: interaction between the Wnt and Notch signalling pathways.

J G Rodríguez-González1, M Santillán, A C Fowler

  • 1Unidad Monterrey, CINVESTAV-IPN, Av. Cerro de las Mitras No. 2565, Col. Obispado, 64060 Monterrey NL, México. jrodriguez@cinvestav.mx

Journal of Theoretical Biology
|June 16, 2007
PubMed
Summary

This study models the vertebrate segmentation clock, proposing that the Axin2 gene pathway can function as a molecular clock. A decreasing Wnt3a signaling gradient in the presomitic mesoderm (PSM) may guide somite formation.

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Last Updated: Jul 13, 2026

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
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Published on: February 16, 2017

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A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
08:06

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

Published on: March 19, 2021

Area of Science:

  • Developmental Biology
  • Systems Biology
  • Molecular Biology

Background:

  • The segmentation clock controls somitogenesis in vertebrates.
  • Early models implicated the Notch signaling pathway (e.g., Hes genes).
  • Recent studies suggest Wnt3a signaling (e.g., Axin2) also oscillates and interacts with Notch.

Purpose of the Study:

  • To investigate the role of Axin2 oscillations in the segmentation clock.
  • To explore if Wnt3a signaling gradients act as wavefronts for somite formation.
  • To identify the master oscillator within the segmentation clock network.

Main Methods:

  • Development of a mathematical model based on existing reviews.
  • Analysis of gene interactions within the Notch and Wnt3a pathways.
  • Simulation of molecular dynamics to test hypotheses.

Main Results:

  • The Axin2 feedback loop can function as a molecular clock.
  • A decreasing Wnt3a concentration gradient in the presomitic mesoderm (PSM) can serve as a wavefront.
  • The model provides insights into the master oscillator controlling somitogenesis.

Conclusions:

  • The Wnt3a pathway, through Axin2, plays a crucial role in the segmentation clock.
  • Wnt3a gradients are essential for recording somitogenesis phase and pattern.
  • This work advances our understanding of vertebrate embryonic development.