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Stereochemical integrity of oxazolone ring-containing jadomycins

Charles N Borissow1, Cathy L Graham, Ray T Syvitski

  • 1College of Pharmacy, Burbidge Building, Dalhousie University, 5968 College Street, Halifax, Nova Scotia, B3H 3J5, Canada.

Chembiochem : a European Journal of Chemical Biology
|June 16, 2007
PubMed
Summary

Jadomycins, natural products from Streptomyces venezuelae, feature a unique oxazolone ring. Their biosynthesis and cytotoxicity reveal that alpha-carbon substitution, not stereochemistry, impacts biological activity.

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