Related Experiment Video
Updated: Jul 14, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
[Acute renal failure after gadolinium-containing contrast medium in preexisting chronic renal failure stage II]
Thomas Jürgensen1, Joachim Brossmann, Jörg Dieter Herrlinger
1Medizinische Klinik, Kreiskrankenhaus Rendsburg, Rendsburg.
Background:
Gadolinium-containing contrast media in low concentration as normally used in magnetic resonance imaging are considered to be safe in patients with slightly impaired renal function.
Case Report:
A case of acute renal failure after administration of gadolinium 0.09 mmol/kg body weight in a patient with preexisting mild renal failure (creatinine clearance 55 ml/min) is described. The additional renal damage was partially reversible.
Conclusion:
The reason for the preexisting renal failure was light-chain disease type kappa. This kind of renal damage may be especially susceptible to contrast media toxicity.
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