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[ALK-negative primary gastric anaplastic large cell lymphoma]
Kazuki Koizumi1, Kouichiro Minauchi, Toshio Odani
1Division of Clinical Rheumatology and Haematology, Department of Medicine, Sapporo City General Hospital.
Summary
A 56-year-old woman with anaplastic large cell lymphoma (ALCL) of the stomach achieved complete remission after salvage chemotherapy and autologous stem cell transplant. This case highlights successful treatment for advanced ALCL.
Area of Science:
- Oncology
- Hematology
Background:
- Anaplastic Large Cell Lymphoma (ALCL) is an aggressive non-Hodgkin lymphoma.
- Gastric ALCL is a rare extranodal presentation requiring tailored treatment strategies.
Observation:
- A 56-year-old Japanese woman presented with upper abdominal pain and a Borrmann III type gastric tumor.
- Diagnosis confirmed as ALCL via biopsy; CT revealed stage IIIE disease with lymph node involvement.
Findings:
- Initial CHOP therapy was ineffective, leading to disease progression.
- Salvage chemotherapy followed by autologous peripheral blood stem cell transplantation (APBSCT) was administered.
Implications:
- APBSCT can be an effective salvage strategy for refractory or relapsed gastric ALCL.
- Achieving complete clinical remission (CCR) post-transplant offers a favorable prognosis.