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[Congenital factor XIII deficiency required high-dose factor XIII concentrate in late pregnancy]

Toru Takahashi1, Katsuhiro Hatao, Munehiro Suzukawa

  • 1Division of Hematology, Department of Internal Medicine, Tokuyama Central Hospital.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|June 19, 2007
PubMed

Congenital factor XIII (FXIII) deficiency is a rare congenital hemorrhagic disorder. Since FXIII is an essential factor in pregnancy, pregnant patients with congenital FXIII deficiency should receive adequate replacement of FXIII concentrate. We report here on a 19-year-old pregnant woman with congenital FXIII deficiency. Despite regular replacement of FXIII concentrate, FXIII activity decreased rapidly after 32 weeks of gestation and she had to receive a high-dose of FXIII concentrate until delivery. Careful monitoring of FXIII activity is needed in patients with congenital FXIII deficiency, because FXIII activity may decrease rapidly in late pregnancy.

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