Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex- and Population-Specific Formulas for Glenoid Height-Based Assessment of Glenoid Bone Loss: A Systematic Review and Meta-analysis.

Orthopaedic journal of sports medicine·2026
Same author

Comparison of Long-term Supraspinatus Tear Progression After Arthroscopic Isolated Subscapularis Repair With and Without Comma Tissue Preservation: A Minimum 10-Year MRI Follow-up Study.

The American journal of sports medicine·2026
Same author

Arthroscopic Repair of Anterior Labroligamentous Periosteal Sleeve Avulsion Lesions Achieves Similar Outcomes and Labral Height Compared With Typical Bankart Lesions With Adequate Capsulolabral Release.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association·2026
Same author

Broken Transverse Force Coupling as a Predictor of Poor Prognosis after Lower Trapezius Tendon Transfer.

Clinics in orthopedic surgery·2026
Same author

Platelet-Rich Plasma and Bone Marrow Stimulation in Double-Row Rotator Cuff Repair Does Not Improve Clinical Outcomes but Reduces Retear Rates: A Retrospective Analysis With Propensity Score Matching.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association·2026
Same author

Open Antegrade Muscle Advancement Reduces Retear Rates Compared to Arthroscopic Repair With Intra-articular Release in Subscapularis Tears With Advanced Fatty Infiltration.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association·2026

Related Experiment Video

Updated: Jul 14, 2026

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
12:18

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft

Published on: August 8, 2020

Dermis graft for wound coverage.

Seung-Kyu Han1, Tae-Hwan Yoon, Jung-Bae Kim

  • 1Seoul, Korea From the Department of Plastic Surgery, Korea University College of Medicine.

Plastic and Reconstructive Surgery
|June 19, 2007
PubMed
Summary

Dermis grafts offer improved aesthetic and functional outcomes compared to traditional skin grafts. This study found superior scar quality and patient satisfaction for both recipient and donor sites with dermis grafts.

More Related Videos

Murine Full-thickness Skin Transplantation
07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
09:30

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

Related Experiment Videos

Last Updated: Jul 14, 2026

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
12:18

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft

Published on: August 8, 2020

Murine Full-thickness Skin Transplantation
07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
09:30

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

Area of Science:

  • Dermatology
  • Plastic Surgery
  • Wound Healing

Background:

  • Skin grafting faces challenges with recipient site color match and donor site morbidity.
  • Dermis grafts, de-epithelialized split-thickness skin grafts, aim to mitigate these issues.
  • Key techniques include immediate epidermal return to the donor site and inducing epithelization at the recipient site.

Purpose of the Study:

  • To compare the efficacy of dermis grafts versus regular split-thickness skin grafts.
  • To evaluate healing time, scar condition, and patient satisfaction for both techniques.

Main Methods:

  • A comparative study involving 53 patients receiving dermis grafts and 33 patients receiving regular split-thickness skin grafts.
  • Data collected from April 2001 to March 2004.
  • Assessment of re-epithelialization time, scar characteristics (pigmentation, height, vascularity, pliability), and patient satisfaction.

Main Results:

  • Dermis grafts showed comparable re-epithelialization times to skin grafts at recipient sites (15.5 +/- 1.9 vs 11.8 +/- 1.6 days).
  • Recipient sites with dermis grafts exhibited less severe scarring (pigmentation, height, vascularity) and higher patient satisfaction.
  • Donor sites healed faster with dermis grafts (7.5 +/- 0.8 days) and demonstrated superior scar quality and patient satisfaction compared to skin grafts.

Conclusions:

  • Dermis graft technique offers aesthetic and functional advantages over regular skin grafts.
  • The dermis graft method improves outcomes for both the recipient and donor sites.
  • This technique represents a superior approach for wound coverage in terms of patient outcomes and scar appearance.