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Pharmacologic modification of induced asthma.
Annals of Allergy
|February 1, 1976
Summary
Oral adrenergic drugs and xanthines, like ephedrine and theophylline, can prevent asthma attacks. This study confirms their prophylactic effect against pollen-induced asthma, maintaining cyclic AMP levels.
Area of Science:
- Pharmacology
- Respiratory Medicine
- Allergy Immunology
Background:
- Oral adrenergic substances and phosphodiesterase inhibitors elevate cyclic AMP levels.
- Elevated cyclic AMP is known to have a prophylactic effect on asthma.
Purpose of the Study:
- To evaluate the efficacy of oral adrenergic drugs and xanthines, alone and in combination, in preventing pollen-induced asthma.
- To assess the role of cyclic AMP in the prophylactic action of these drugs.
Main Methods:
- Controlled, double-blind study design.
- Inclusion of highly selected patients with pollen-induced asthma.
- Administration of adrenergic drugs and xanthines, individually and combined.
Main Results:
- Both oral adrenergic drugs and xanthines demonstrated a prophylactic effect against induced asthma.
- The drug combination showed efficacy in blocking asthma symptoms.
- The mechanism involves maintaining high cyclic AMP levels in target cells.
Conclusions:
- Oral adrenergic drugs and xanthines are effective in asthma prophylaxis.
- These medications can be valuable for preventing asthma triggered by allergens.
- The findings support the use of these agents for asthma management.