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Published on: February 2, 2024
Chronic pancreatitis with synchronous and metachronous malignancy: three unusual cases and a literature review
Michael Wayne1, Avram Cooperman, Franklin Kasmin
1Department of Surgery, Cabrini Medical Center, New York, NY 1003, USA. waynedocny@hotmail.com
Hypothesis:
Chronic pancreatitis is a risk factor for pancreatic cancer. The association between these 2 disease processes is not well known. We present 3 unusual cases of pancreatitis associated with pancreatic cancer and review the possible mechanisms that can cause pancreatitis to degenerate into pancreatic cancer.
Design:
A case series reviewing 3 unusual cases of chronic pancreatitis associated with pancreatic cancer. The patients' charts are reviewed, and a literature search is performed looking for chronic pancreatitis associated with pancreatic cancer.
Setting:
The cases were performed at a small community hospital in New York City, New York.
Participants:
The surgeons involved are experienced pancreatic surgeons with a large referral group. The endoscopies were performed by gastroenterologists with years of experience in biliary and pancreatic disease.
Results:
The cases and the literature review support the hypothesis that there is an association between chronic pancreatitis and pancreatic cancer.
Conclusions:
Three unusual case of chronic pancreatitis, 2 with synchronous and 1 with metachronous malignancies, are presented. The pathway of benign to malignant change is reviewed, and the constant awareness that pancreatitis is associated with malignancy must be kept in mind.
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Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction
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Assessment:
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Acute Pancreatitis II: Pathophysiology