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Prostatic stem cell marker identified by cDNA microarray in mouse.

Akira Tsujimura1, Kazutoshi Fujita, Kazuhiko Komori

  • 1Department of Urology, Osaka University Graduate School of Medicine, Suita and Osaka Police Hospital, Osaka, Japan. atitsuji@uro.med.osaka-u.ac.jp

The Journal of Urology
|June 19, 2007
PubMed
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Researchers identified prominin as a novel marker for mouse prostatic stem cells in the proximal region. Prominin-positive cells demonstrated stem cell characteristics, including self-renewal and differentiation potential in 3D cultures.

Area of Science:

  • Urology
  • Stem Cell Biology
  • Cancer Research

Background:

  • Prostatic stem cells are crucial for prostate development and understanding prostate cancer.
  • Previous research identified stem cells in the mouse prostate's proximal region.
  • A specific marker for these proximal prostatic stem cells was previously unknown.

Purpose of the Study:

  • To identify a specific marker for prostatic stem cells in the proximal region of the mouse prostate.
  • To elucidate the role of this marker in prostate development and cancer.

Main Methods:

  • Performed cDNA microarray analysis on cells from proximal and remaining dorsal prostate regions.
  • Utilized reverse transcriptase-polymerase chain reaction and immunohistochemistry to confirm candidate gene expression.

Related Experiment Videos

  • Investigated the functional potential of marker-positive cells in 3D culture.

    • Main Results:

    • Identified prominin as a candidate stem cell marker based on microarray analysis.
    • Confirmed a prominin-positive cell population in the proximal region's basal layer.
    • Prominin-positive cells exhibited stem cell properties, forming branched ducts in 3D culture.

    Conclusions:

    • Prominin is a specific marker for prostatic stem cells in the proximal region of the mouse prostate.
    • These prominin-positive cells represent a functional stem cell population with regenerative potential.