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Updated: Jul 14, 2026

Breathing-controlled Electrical Stimulation (BreEStim) for Management of Neuropathic Pain and Spasticity
11:34

Breathing-controlled Electrical Stimulation (BreEStim) for Management of Neuropathic Pain and Spasticity

Published on: January 10, 2013

[Regulation of respiration: visceral and behavioural components]

I S Breslav, A D Nozdrachev

    Uspekhi Fiziologicheskikh Nauk
    |June 21, 2007
    PubMed

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    Physiological Control of Respiration01:23

    Physiological Control of Respiration

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    Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
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    Central Control
    The brainstem is the primary site of central control, hosting respiratory centers:
    Neural Control of Respiration01:18

    Neural Control of Respiration

    The neural regulation of respiration is a meticulously coordinated process primarily controlled by the respiratory centers located within the brainstem. These centers, composed of specialized neurons, transmit nerve impulses that control the contraction and relaxation of our respiratory muscles.
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    Other Factors Affecting Respiration Centers01:17

    Other Factors Affecting Respiration Centers

    Breathing is primarily an involuntary activity regulated by the brainstem respiratory centers. However, it can also be consciously controlled, allowing us to hold our breath or take deeper breaths when needed. This voluntary control is facilitated by the cerebral motor cortex, which bypasses the medullary centers to stimulate the respiratory muscles directly.
    However, the ability to hold one's breath voluntarily is not limitless. When the CO2 concentration in the blood reaches a critical level,...
    Chemical Factors Affecting Respiration Centers01:31

    Chemical Factors Affecting Respiration Centers

    Chemical factors such as changing CO2, O2, and H+ levels in arterial blood play a critical role in influencing respiration depth and rates. These variations are detected by chemoreceptors—specialized sensors located in two primary body areas. Central chemoreceptors are found throughout the brain stem, including the ventrolateral medulla, while peripheral chemoreceptors are located in the aortic arch and carotid arteries.
    CO2 has a potent influence on respiration and is strictly regulated. Under...
    Respiratory Regulation of Acid-Base Balance01:18

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