[Statistical analysis in epidemiological studies of urolithiasis in the South Urals]

The aim of the study was mathematical estimation of causes and conditions of urolithiasis onset in the territory of the South Urals. The data on 18 potential risk factors were obtained from 106 sitizens of the Chelyabinsk region suffering from urolithiasis and 69 controls free of renal pathology. The data on 18 potential risk factors were obtained from 106 sitizens of the Chelyabinsk region suffering from urolithiasis and 69 controls free of renal pathology. Statistical analysis was made on the risk factors including stress estimation by the index of functional alterations, calculation of odds ratio by contingency tables, multidimentional scaling with variance analysis of the scales and creation of the decision tree. It was found that main causes of urolithiasis in the South Urals are direct inheritance (36.8%, probability increased 39 and more times), model of metabolism with signs of metabolic syndrome. Predisposition realization was related to environmental pollution and nutritional factors. In etiology of urolithiasis the metabolic factor was more essential in women gaining importance with age. Environmental factors were more significant for men. Thus, up-to-date methods of statistical analysis in the epidemiological study of urolithiasis patients allowed the investigators to single out leading factor--hereditary predisposition and metabolism model. The other risk factors may promote the disease onset.