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Human IgM+CD27+ B cells: memory B cells or "memory" B cells?

Stuart G Tangye1, Kim L Good

  • 1Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia. s.tangye@garvan.org.au

Journal of Immunology (Baltimore, Md. : 1950)
|June 21, 2007
PubMed
Summary
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Human memory B cells, identified by CD27 expression, contribute to immunity. This review proposes that IgM+CD27+ B cells are indeed memory cells, challenging prior interpretations of their role in immune responses.

Area of Science:

  • Immunology
  • Cell Biology
  • Serological Immunity

Background:

  • Memory B cells are crucial for rapid secondary immune responses.
  • Human memory B cells are typically identified by CD27 expression.
  • A subset of CD27+ B cells express IgM, leading to debate about their memory status.

Purpose of the Study:

  • To re-evaluate the classification of IgM+CD27+ B cells.
  • To propose alternative interpretations of their biological function.
  • To argue for their role as genuine memory B cells.

Main Methods:

  • Review of existing literature on B cell populations.
  • Analysis of data regarding B cell differentiation and antigen response.
  • Interpretation of studies on germinal center-independent B cell generation.

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Main Results:

  • CD27+ B cells express mutated Ig V region genes.
  • Some mutated CD27+ B cells retain IgM expression.
  • Existing data can be interpreted to support IgM+CD27+ B cells as memory cells.

Conclusions:

  • IgM+CD27+ B cells may represent a distinct memory B cell subset.
  • Their generation might occur independently of germinal centers.
  • These cells likely contribute to adaptive immunity through T cell-dependent or independent pathways.