[Why are collagenoses dangerous for pregnancy?]

It is well known that certain autoimmune disorders are associated with pregnancy loss. Increased perinatal and maternal mortality as well as increased incidence of disease deterioration during pregnancy are correlated to preconceptual disease regulation, incidence of super-imposed gestosis and renal failure and, recently, with some sorts of antiphospholipid antibodies. Indeed, investigators have attempted to establish an association between recurrent pregnancy loss and the presence of specific antibodies, irrespective of the presence of other clinical signs or complications of collagenosis. The most serious appears to be the presence of anticardiolipin antibodies and lupus anticoagulant while the significance of other autoantibodies that can be found appears to be much less defined. In the present paper pregnancy complicated by various collagenoses and therapeutic modalities are discussed.