Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Sample Preparation for Analysis: Overview

Sample Preparation for Analysis: Overview

Sample preparation is an essential step in the analytical process. It involves preparing a sample so that it can be analyzed accurately. The goal is to extract the analyte, the substance you want to measure, from the sample while removing any components that may interfere with the analysis. Sample preparation techniques vary depending on the physical state of the sample.
Bulk or large solid samples are typically reduced in size using grinding, crushing, or milling techniques to increase the...

Sample Preparation for Analysis: Advanced Techniques

Sample Preparation for Analysis: Advanced Techniques

Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...

Washing, Drying, and Ignition of Precipitates

Washing, Drying, and Ignition of Precipitates

After filtration, the precipitate is washed to remove coprecipitated impurities and any remaining mother liquor. Colloidal precipitates, such as silver chloride, are washed with an electrolyte (such as dilute nitric acid) to prevent the peptization of the precipitate. In the case of slightly soluble precipitates, the wash solution contains a common ion to reduce solubility. Lead sulfate, which is slightly soluble in water, is washed with dilute sulfuric acid. Similarly, wash solutions may be...

Precipitation and Co-precipitation

Precipitation and Co-precipitation

Precipitation and coprecipitation methods can be used to separate a mixture of ions in a solution. In qualitative inorganic analysis, ions that form sparingly soluble precipitates with the same reagent are separated based on the differences in solubility products. For example, consider the separation of Cu(II) and Fe(II) ions by precipitation as insoluble sulfides. First, copper(II) sulfide is precipitated by the addition of acidic H2S, where the dissociation of H2S is suppressed. Adding H2S...

Preparation of Samples for Electron Microscopy

Preparation of Samples for Electron Microscopy

To be visualized by an electron microscope, either transmission or scanning, biological samples need to be fixed (stabilized) so the electron beam does not destroy them and dried thoroughly (desiccated/dehydrated) so the vacuum does not affect them. Fixation needs to be done as quickly as possible because the sample properties will start changing as soon as it is removed from its natural environment. For example, in a tissue sample, the oxygen levels begin decreasing, causing an altered...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Perithyroidal Adipose Tissue Drives Thyroid Tumorigenesis through Adipokine Signaling and Immune Suppression.

Research (Washington, D.C.)·2026

Same author

Gold Nanoplatforms for Phenotypic Reprogramming and Closed-Loop Theranostics of Cancer Stem Cells.

International journal of nanomedicine·2026

Same author

Tanshinone IIA Ameliorates Heart Failure by Inhibiting Ferroptosis via the Sirt1/p53/GPX4 Signaling Pathway.

The American journal of Chinese medicine·2026

Same author

Correlation between surrogate indicators of insulin resistance and all-cause mortality in patients with severe hemorrhagic stroke: a multicenter retrospective cohort study in the United States.

Cardiovascular diabetology·2026

Same author

Advanced magnetic resonance neurography for preoperative facial nerve assessment and surgical planning in parotid tumors: a review of current evidence and surgical translation.

Frontiers in oncology·2026

Same author

MDFAT: Interactive mask decoupling and frequency-adaptive transformer for multi-focus image fusion.

Neural networks : the official journal of the International Neural Network Society·2026

Search research articles

Related Experiment Video

Updated: Jul 14, 2026

Clean Sampling and Analysis of River and Estuarine Waters for Trace Metal Studies

Clean Sampling and Analysis of River and Estuarine Waters for Trace Metal Studies

Published on: July 1, 2016

[Applications of monoliths in sample preconcentration].

Fang Wei¹, Bo Lin, Yuqi Feng

¹Department of Chemistry, Wuhan University, Wuhan 430072, China.

Se Pu = Chinese Journal of Chromatography

|June 22, 2007

Summary

This review explores monoliths for sample preconcentration, highlighting their integration with chromatography and microfluidic systems. It covers recent advancements and applications in analytical chemistry.

More Related Videos

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides

Published on: July 14, 2015

Fabrication of a Dipole-assisted Solid Phase Extraction Microchip for Trace Metal Analysis in Water Samples

Fabrication of a Dipole-assisted Solid Phase Extraction Microchip for Trace Metal Analysis in Water Samples

Published on: August 7, 2016

Related Experiment Videos

Last Updated: Jul 14, 2026

Clean Sampling and Analysis of River and Estuarine Waters for Trace Metal Studies

Clean Sampling and Analysis of River and Estuarine Waters for Trace Metal Studies

Published on: July 1, 2016

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides

Published on: July 14, 2015

Fabrication of a Dipole-assisted Solid Phase Extraction Microchip for Trace Metal Analysis in Water Samples

Fabrication of a Dipole-assisted Solid Phase Extraction Microchip for Trace Metal Analysis in Water Samples

Published on: August 7, 2016

Area of Science:

Analytical Chemistry
Separation Science
Materials Science

Context:

Sample preconcentration is crucial for trace analysis.
Monolithic materials offer unique advantages in chromatography and separation science.
Integrating preconcentration with separation techniques enhances analytical efficiency.

Purpose:

To review the development and applications of monoliths in sample preconcentration.
To highlight monolith preconcentration coupled with various separation techniques.
To present novel modes of monolith preconcentration.

Summary:

This review details the use of monoliths for sample preconcentration.
Applications coupled with high-performance liquid chromatography, capillary electrophoresis, capillary electrochromatography, and microfluidic chips are emphasized.
Recent advancements in monolith preconcentration techniques are also discussed.

Impact:

Provides a comprehensive overview of monoliths in analytical sample preparation.
Facilitates understanding of advanced preconcentration strategies.
Serves as a resource for researchers in separation science and analytical chemistry.