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Updated: Jul 14, 2026

Modeling an Enzyme Active Site using Molecular Visualization Freeware
Published on: December 25, 2021
Synthesis of nitric oxide reductase active site models bearing key components at both distal and proximal sites
James P Collman1, Ying Yang, Richard A Decréau
1Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. jpc@stanford.edu
Abstract:
Porphyrins 1ab and 2ab were successfully synthesized from cis-alpha2-bisimidazole-beta-imidazole-tail porphyrins and two newly synthesized imidazole pickets containing an aliphatic ester chain following a [2+1] approach. The four compounds possess a distal trisimidazole set, a distal carboxylic acid, and a proximal imidazole, which constitute all the key features of the coordination environment of the active site in Bacterial Nitric Oxide Reductase (NOR) and make them the closest synthetic NOR model ligands to date.
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