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[Different courses of esomeprazole-based triple therapy for Helicobactor pylori infection in children]

Li Xiang1, Fei-Qiu Wen, Wei-Hua Zuo

  • 1Department of Pediatrics, Second Affiliated Hospital, Medical College of Jinan University, Shenzhen, Guangdong 518020, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|June 22, 2007
PubMed

Insights

Esomeprazole-based triple therapy effectively eradicates Helicobacter pylori (H. pylori) in children. Both 1-week and 2-week treatment durations show similar efficacy, with symptom relief and high H. pylori eradication rates observed in both groups.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Pharmacology

Background:

  • Helicobacter pylori (H. pylori) infection is a common cause of recurrent abdominal pain in children.
  • Standard triple therapy regimens are used for H. pylori eradication, but optimal duration in pediatric populations is still being studied.

Purpose of the Study:

  • To evaluate the efficacy of 1-week versus 2-week esomeprazole-based triple therapy for H. pylori eradication in children.
  • To assess the impact of treatment duration on symptom resolution and eradication rates.

Main Methods:

  • A randomized study involving 105 children with H. pylori infection confirmed by 13C-UBT.
  • Participants were assigned to receive either 1 week (Group A) or 2 weeks (Group B) of triple therapy (esomeprazole, clarithromycin, amoxicillin).
  • Efficacy was assessed by 13C-UBT negativity and symptom recurrence four weeks post-treatment.

Main Results:

  • All patients experienced relief from recurrent abdominal pain.
  • H. pylori eradication rates were high in both groups: 91.7% in Group A and 93.3% in Group B.
  • No significant difference in H. pylori eradication rates was observed between the 1-week and 2-week treatment durations.

Conclusions:

  • Esomeprazole-based triple therapy is an effective treatment for H. pylori infection in children.
  • A 1-week treatment duration appears to be as effective as a 2-week duration for H. pylori eradication in this pediatric cohort.
  • These findings support the use of shorter-duration esomeprazole-based triple therapy for H. pylori in children.
Abstract

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