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Esophageal damages in systemic scleroderma.

Valbona Duraj1, Argjent Tafai, Enver Roshi

  • 1Rheumatology Unit, University Hospital Center "Mother Teresa", Tirana, Albania. valbonaduraj@yahoo.com

Medicinski Arhiv
|June 23, 2007
PubMed
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Scleroderma patients frequently experience esophageal damage, with nearly all showing issues. Motor dysfunction is the most common esophageal problem in those with this autoimmune condition.

Area of Science:

  • Rheumatology
  • Gastroenterology
  • Immunology

Background:

  • Scleroderma is an autoimmune disease characterized by fibrosis and vascular abnormalities.
  • Gastrointestinal involvement is common in scleroderma, significantly impacting patient quality of life.

Purpose of the Study:

  • To determine the prevalence of esophageal damage in scleroderma patients.
  • To investigate associations between esophageal damage and skin/immunological alterations.

Main Methods:

  • A case-series study involving 74 scleroderma patients (2003-2006).
  • Data included clinical information, laboratory analyses, and esophageal radioscopy.
  • Patients were recruited from the Rheumatology Unit, University Hospital Center, Tirana.

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Main Results:

  • Esophageal damage was highly prevalent, found in approximately 97% of patients.
  • Prevalence was similar between sexes and highest in the 36-50 age group.
  • Esophageal damage correlated with skin alterations (77%) and anti-nuclear antibody (AAN) positivity (76%).

Conclusions:

  • High rates of gastrointestinal damage, particularly esophageal, are confirmed in scleroderma.
  • Motor dysfunction represents the most frequent type of esophageal damage observed.