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Moexipril and left ventricular hypertrophy.

George S Chrysant1, P K Nguyen

  • 1University of Oklahoma, Oklahoma City, USA. gsc5@yahoo.com

Vascular Health and Risk Management
|June 23, 2007
PubMed
Summary
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Angiotensin-converting enzyme (ACE) inhibitors, like moexipril hydrochloride, effectively treat hypertension and improve heart function after myocardial infarction. These drugs promote regression of left ventricular hypertrophy (LVH), a key risk factor for cardiovascular disease.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Angiotensin-converting enzyme (ACE) inhibitors are standard therapy for myocardial infarction and heart failure.
  • ACE inhibitors improve left ventricular remodeling and function, and induce regression of left ventricular hypertrophy (LVH).
  • LVH is an independent risk factor for cardiovascular morbidity and mortality.

Purpose of the Study:

  • To evaluate the effects of moexipril hydrochloride on left ventricular hypertrophy (LVH).

Main Methods:

  • Moexipril hydrochloride is a long-acting, non-sulfhydryl ACE inhibitor for once-daily hypertension treatment.

Main Results:

  • Moexipril hydrochloride demonstrated beneficial effects on LVH.
  • Moexipril hydrochloride can lead to LVH regression.

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Conclusions:

  • Moexipril hydrochloride offers a therapeutic option for patients with hypertension and LVH.
  • The mechanism of LVH regression by ACE inhibitors likely involves more than blood pressure reduction.