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Related Experiment Video

Updated: May 18, 2026

Behavioral Assessment of Manual Dexterity in Non-Human Primates
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Behavioral Assessment of Manual Dexterity in Non-Human Primates

Published on: November 11, 2011

Improving lesion-symptom mapping.

Chris Rorden1, Hans-Otto Karnath, Leonardo Bonilha

  • 1Department of Communication Sciences and Disorders, University of South Carolina, SC 29208, USA. chris@mricro.com

Journal of Cognitive Neuroscience
|June 23, 2007
PubMed
Summary
This summary is machine-generated.

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Voxel-based lesion mapping reveals crucial brain regions for function. New statistical tests, the Liebermeister approach and Brunner and Munzel test, improve accuracy over traditional methods for analyzing brain injury data.

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Neurology

Background:

  • Brain activation studies are popular but do not identify crucial regions.
  • Examining brain disruption, like after injury, complements activation studies.
  • Voxel-based lesion mapping links behavior to brain injury location.

Purpose of the Study:

  • To introduce more sensitive statistical tests for voxel-based lesion mapping.
  • To compare the effectiveness of new statistical tests against traditional ones.
  • To provide freely available software for implementing these advanced statistical methods.

Main Methods:

  • Compared the chi-square test with the Liebermeister approach for binomial data.
  • Compared Student's t test with the Brunner and Munzel test for nonbinomial data.

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Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
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Published on: September 25, 2019

Related Experiment Videos

Last Updated: May 18, 2026

Behavioral Assessment of Manual Dexterity in Non-Human Primates
16:00

Behavioral Assessment of Manual Dexterity in Non-Human Primates

Published on: November 11, 2011

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
10:25

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

  • Validated statistical tests using simulated data and stroke patient data.

    • Main Results:

    • The Liebermeister approach showed higher sensitivity for binomial data.
    • The Brunner and Munzel test is more appropriate for nonbinomial clinical data.
    • Developed and released MRIcron software for implementing these statistical tests.

    Conclusions:

    • The proposed statistical tests offer improved sensitivity and appropriateness for lesion mapping.
    • Accurate statistical analysis is crucial for understanding brain function through lesion studies.
    • Freely available software facilitates the adoption of advanced lesion mapping techniques.