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Paraneoplastic syndromes.

J B Posner1

  • 1Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York.

Neurologic Clinics
|November 1, 1991
PubMed
Summary
This summary is machine-generated.

Systemic cancer can cause neuromuscular complications through direct tumor effects, treatment side effects, or remote paraneoplastic syndromes. These syndromes include diverse neurological disorders affecting nerves and muscles.

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Area of Science:

  • Neurology
  • Oncology
  • Cancer Research

Background:

  • Systemic cancer presents with diverse neuromuscular complications.
  • These complications arise from direct tumor effects, cancer treatments, or remote effects.
  • Remote effects manifest as paraneoplastic syndromes.

Purpose of the Study:

  • To outline the spectrum of neuromuscular complications associated with systemic cancer.
  • To categorize these complications based on their underlying mechanisms.

Main Methods:

  • Review of existing literature on cancer-related neuromuscular disorders.
  • Classification of complications into direct, treatment-related, and remote effects.

Main Results:

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  • Direct effects involve nerve compression or infiltration by tumor cells.
  • Treatment-related effects stem from radiation and chemotherapy.
  • Remote effects encompass paraneoplastic syndromes like motor neuron disease, polyneuropathies, Lambert-Eaton myasthenic syndrome, and inflammatory myopathies.

    • Conclusions:

    • Neuromuscular complications are a significant aspect of systemic cancer management.
    • Understanding these complications is crucial for accurate diagnosis and treatment.
    • Paraneoplastic syndromes represent a key category of remote neuromuscular effects in cancer patients.