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Related Experiment Videos

The positive T wave.

Mark Potse1, Ruben Coronel, Tobias Opthof

  • 1Department of Physiology, Institute of Biomedical Engineering, Université de Montréal, Montréal, Québec, Canada. mark@potse.nl

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|August 1, 2007
PubMed
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This summary is machine-generated.

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The instant of maximum slope (Tup) of the T wave accurately predicts repolarisation time (TR), even for positive T waves. This finding clarifies T wave mechanisms and confirms Tup as a reliable measure of TR.

Area of Science:

  • Cardiac Electrophysiology
  • Computational Biology
  • Biomedical Engineering

Background:

  • The instant of maximum slope (Tup) of the T wave in unipolar electrograms is a standard measure of repolarisation time (TR).
  • Recent studies have sparked debate regarding the interpretation of positive T waves.
  • Understanding the mechanisms behind T wave polarity is crucial for accurate TR assessment.

Purpose of the Study:

  • To elucidate the mechanisms underlying positive and negative T waves.
  • To determine which electrogram feature best predicts repolarisation time (TR).
  • To investigate the reliability of Tup for TR assessment in various T wave polarities.

Main Methods:

  • Simulated propagating action potentials and electrograms using a bidomain reaction-diffusion model of the human heart.

Related Experiment Videos

  • Incorporated heterogeneous ion-channel properties into the cardiac model.
  • Compared simulation results with a simplified model predicting T waves from local and remote action potentials.

    • Main Results:

    • Repolarisation time (TR) was defined by the steepest downstroke of the action potential.
    • T wave polarity is predominantly determined by TR, with positive T waves originating from early-repolarising sites.
    • A high correlation (>0.99) was observed between Tup and TR for both negative and positive T waves.
    • T wave area and peak value also demonstrated strong correlations with TR.

    Conclusions:

    • T wave polarity is primarily dictated by repolarisation time (TR).
    • Positive T waves are associated with early-repolarising cardiac regions.
    • The instant of maximum slope (Tup) is the most accurate predictor of local TR, including cases with positive T waves.