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Updated: Jul 14, 2026
07:56
Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
Acutely and retrospectively diagnosed perinatal stroke: a population-based study
Rael Laugesaar1, Anneli Kolk, Tiiu Tomberg
1Children's Clinic of Tartu University Hospital, Tartu, Estonia. Rael.Laugesaar@kliinikum.ee
Stroke
|June 23, 2007
Summary
Perinatal stroke incidence in Estonia is 63 per 100,000 live births, higher than previously reported. Early diagnosis of perinatal stroke is crucial for better outcomes and improved clinical recognition.
Area of Science:
- Neurology
- Pediatrics
- Epidemiology
Background:
- Perinatal stroke is considered underdiagnosed due to limited epidemiological data.
- This study addresses the need for more comprehensive data on perinatal stroke incidence and characteristics.
Purpose of the Study:
- To estimate the incidence of perinatal arterial ischemic and hemorrhagic stroke in Estonia.
- To investigate the initial clinical signs of perinatal stroke.
- To compare predisposing factors and outcomes between acutely and retrospectively diagnosed cases.
Main Methods:
- A retrospective and prospective study was conducted in Estonia from 1994 to 2003.
- Cases were identified through pilot studies, hospital records, and inquiries to child neurologists and general practitioners.
- Diagnosis was confirmed in 38 cases using neuroradiology (MRI or CT).
Main Results:
- The incidence of perinatal stroke was found to be 63 per 100,000 live births.
- Common neonatal clinical findings included seizures, abnormal muscle tone, and altered alertness.
- Children with early diagnosis showed more adverse pregnancy/delivery events and severe hemiparesis compared to those diagnosed later.
Conclusions:
- The incidence rate of 63 per 100,000 live births is higher than previously reported, suggesting underdiagnosis.
- Analyzing early clinical signs of perinatal stroke can enhance diagnostic accuracy and timeliness.
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