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Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
Published on: September 20, 2019
Spindle cell lipoma.
Nil Comunoglu1, Cem Comunoglu, A Işin Dogan Ekici
1Yeditepe University School of Medicine Department of Pathology, Istanbul, Turkey. ncomunoglu@yeditepe.edu.tr
Summary
Spindle cell lipomas are benign tumors often found on the back and shoulder. These tumors are consistently CD34 positive and desmin negative, aiding in their differentiation from similar soft tissue neoplasms.
Area of Science:
- Soft tissue pathology
- Oncology
- Dermatopathology
Background:
- Spindle cell lipomas are benign lipogenic tumors.
- They typically affect elderly males on the posterior back and shoulder.
- Increasing reports of similar tumors like myofibroblastomas necessitate clear diagnostic criteria.
Purpose of the Study:
- To evaluate the clinicopathological and immunohistochemical features of spindle cell lipomas.
- To identify key markers for differentiating spindle cell lipomas from other spindle cell tumors.
- To confirm the utility of desmin negativity in distinguishing spindle cell lipomas.
Main Methods:
- Retrospective analysis of 18 spindle cell lipoma cases.
- Histopathological examination of tumor morphology.
- Immunohistochemical analysis including CD34 and desmin expression.
Main Results:
- All 18 cases (15 classical, 3 pleomorphic variant) showed characteristic histology.
- All cases were immunohistochemically CD34 positive.
- Ten available cases were desmin negative.
Conclusions:
- Spindle cell lipomas are characterized by bland spindle cells, mature adipocytes, and collagen bundles.
- CD34 positivity is a consistent feature.
- Desmin negativity is a key feature that helps differentiate spindle cell lipomas from extramammary myofibroblastomas.
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